The Science of Obesity & Why The Carbohydrate-Insulin Model of Obesity is Probably Wrong || Stephan Guyenet

Obesity is a complicated problem and the solution may lie in a multi-prong approach. We look at what the science tells us about obesity, how various properties of foods can impact consumption, discuss the Carbohydrate Insulin Hypothesis and understand how the brain and body responds to an obesogenic environment.


Stephan J. Guyenet, PhD is a former neuroscience and obesity researcher and author of the book The Hungry Brain: Outsmarting the Instincts That Make Us Overeat, which was named one of the best books of 2017 by Publishers Weekly. His research has been cited more than 2,000 times by his scientific peers. His writing and speaking focus on the brain circuits that regulate eating behavior and body fatness, and how we can work with them to sustainably manage our waistlines.


12:45 – Stephan’s journey into neuroscience and obesity research

16:06 – What caused obesity in humans?

20:22 – The connection between smoking and obesity?

22:32 – Why does every new diet trend such as paleo fail to reverse obesity crisis?

30:31 – Why focusing purely on taste and flavor to gauge food could be obesogenic.

36:36 – Why pure sugar and pure fat are difficult to consume but in the right combination can be addictive and be overconsumed?

45:49 – How sensory variety could lead to overconsumption

48:40 – NUSI study and why Carbohydrate Insulin Hypothesis isn’t the sole driver of obesity

59:39 – Can eating fat raise insulin over time?

1:04:04 – How the food industry is incentivized to create obesogenic foods

1:08:11 – What drives cravings?

1:10:45 – Is short term overconsumption a good predictor of long term overconsumption

1:14:04 – Does sugar addiction exist?

1:17:20 – Understanding what kind of animal studies are relevant and which aren’t

1:21:03 – What kind of research would you like to see?