Cholesterol, Statins, Philosophy, Science, Processed Foods & a Huge Bag of Wisdom || Nick Mailer

A VERY long awaited special 50th episode where we delve into the bigger picture while discussing many topics including the biochemistry of cholesterol & statins, the scientific method, philosophy, processed foods and top it off with a dose of what we can learn from evolution and how to lead a fulfilling life. This one is a GREAT episode!


After obtaining a degree from the University of Leeds in English and Philosophy, Nick Mailer co-authored the first book in the UK on the education possibilities of the Internet. He co-founded The Positive Internet Company, UK's premier open-source managed services organisation. He also founded the Campaign for Unmetered Telecommunications.

He has spoken at conferences, including the Ancestral Health Symposium and Ketofest, on the nexus of culture, technology and semiotics. Since 2010, he has adopted a paleo-ish LCHF lifestyle, to which he nevertheless applies a multidisciplinary scepticism! He lives in London with his wife, daughter and cat.


0:15 - Epic Superhero Intro

9:13 - How did you get into Low Carb?

14:23 - A philosophical perspective, paradoxes and the impracticality of certain scientific models

18:40 - How different people handle paradoxes against their knowledge

20:55 - Will we get the next Galileo or Einstein in the world of science and research?

24:38 - Paradigm shifts in modern science and repeating human patterns when confronted with conflicting knowledge

29:26 - Meaning of a statement may be a method of of its verification

32:25 - What is a "Black Swan", Cholesterol and the narrative of the Kitavans

37:15 - PURE study and what knowledge you can obtain from observational studies

39:09 - Mevalonate pathway, statins and the importance of simplifying and understanding science

44:30 - The role of cholesterol, how statins disrupt the body's mechanisms and the impact of statins on a cellular level

47:51 - Why anyone can now obtain knowledge and should embrace complexity and details

52:00 - Concerns when people outsource critical thinking on social media forums and groups

55:42 - Pros and cons of deferring to an authority and how to ground yourself in a sea of too much information

1:06:05 - Difference between the pleasure of eating and the pain of eating

1:12:08 - Human adaptations, homeostatic mechanisms, hormones and brain rewards

1:16:15 - Thinking of & troubleshooting the body as a slowly self-learning software

1:21:20 - Why using food processing in a negative connotation is a limited way of thinking

1:24:35 - A discussion about sweeteners: erythritol and aspartame

1:28:33 - The benefit of not nuking your palate with sweeteners

1:34:46 - The bigger picture, living a happy life and lessons we can obtain from evolution

1:45:44 - Final Plugs







Fahad is the founder of Ketogeek and hosts the Ketogeek Podcast, a world class health show about food, nutrition and health. He is into resistance training, Ashtanga yoga, calisthenics and various forms of training styles. Armed with a idealistic goals distilled in a world of realism, his goal is to help the world make a better place. He leads a life of extreme generalism or as he describes it, 'The Renaissance Lifestyle'.